منابع مشابه
Role of Endothelins
Accessible online at: http://BioMedNet.com/karger Hyperdynamic circulation as well as increased hepatic resistance contribute to portal hypertension in cirrhosis of the liver [1]. Hyperdynamic circulation with increased cardiac output, heart rate and plasma volume and decreased arterial blood pressure and systemic vascular resistance are characteristic in advanced cirrhosis. Systemic and splanc...
متن کاملEndothelins in regulating ovarian and oviductal function.
In the last 30 years, remarkable progress has been made in our understanding of the biological role of endothelins in the regulation of reproductive function and fertility. A peptide hormone identified for its ability to regulate blood pressure has now been shown as a potent mediator of several reproductive pathways. Ligand- and receptor-specific roles have been identified and/or postulated dur...
متن کاملEndothelins : Their Current Status and Future Prospects
Endothelins are potent peptide vasoconstrictors which were discovered two decades back. Their role in cardiovascular diseases, cancer, glaucoma, diabetes mellitus and many other diseases have been studied. Inspite of a lot of research many questions regarding their pathophysiological roles still remain unanswered. Though many endothelin receptor antagonists showed promising results in animal st...
متن کاملEndothelins and their Receptors in the Lung
Endothelins (ETs), first discovered as potent vasoconstrictors, are a family of polypeptides with a wide range of activities in the airvays and pulmonary vascular system. Synthesized by respiratory epithelium and by pulmonary vascular endothelium, ETs, as a potent bronchoconstrictors and mitogens, may play a role in the pathogenesis of pulmonary hypertension and bronchial asthma. ETs are a part...
متن کاملEndothelins and hypoxia-inducible factor in cancer.
The endothelin system is a family of three similar small peptides, two G-protein-coupled receptors and two proteinases. Endothelins have several physiological roles, notably in embryonic differentiation and vascular homeostasis. Numerous types of tumour express endothelins and their regulation is often aberrant when compared with the normal tissue from which the tumour arose. However, endotheli...
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ژورنال
عنوان ژورنال: Postępy Higieny i Medycyny Doświadczalnej
سال: 2016
ISSN: 1732-2693
DOI: 10.5604/17322693.1214386